Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition

Inflammation is associated with the development of several diseases comprising cancer and cardiovascular disease. Agents that suppress cyclooxygenase (COX) lipoxygenase (LOX) enzymes, besides chemokines have been suggested to minimise inflammation. Here, a variety novel heterocyclic non-heterocyclic compounds were prepared from three furanone derivatives. The structures all synthesised confirmed by elemental spectral analysis including mass, IR, 1H-NMR spectroscopy. Anti-inflammatory activities these examined in vitro against COX 15-LOX, tumour necrosis factor-α (TNF-α), using inhibition screening assays. majority derivatives showed significant high activities, pyridazinone (5b, 8b, 8c) being most promising anti-inflammatory agents dual COX-2/15-LOX along TNF-α activity.